THERAPEUTIC COOLING

Reducing Fever

Clinical studies have shown that elevated body temperature in neurologic intensive care patients is associated with a longer ICU and hospital length of stay (LOS), higher mortality rate and worse outcomes.¹

Incidence of Fever in Neurointensive Care Unit

Alsius IVTM™ System was shown to be 64% more effective than surface cooling techniques for fever reduction in neurologic intensive care unit patients.²

Induced Hypothermia

Many hospitals are adopting the American Heart Association guidelines³ for treatment of cardiac arrest. Clinical studies have shown that induced hypothermia in patients resuscitated after cardiac arrest helps to prevent neurologic damage and improve outcomes.⁴ These caregivers understand the temperature management challenges of implementing this protocol including:

• lower the temperature (32°-34°C)
• maintain target temperature for 12-24 hours
• controlled rewarm back to normal temperatures (37°C)
• prevent rebound fever

Induced Hypothermia

Patients cooled with the Alsius IVTM™ System had 2-fold increased odds of survival and had significantly reduced mortality and improved favorable neurological recovery at 30 days compared with the control group.⁵

Market clearances vary by geographic region. Please refer to Indications for Use reference literature for market clearance indications.

1. Elevated Body Temperature Independently Contributes to Increased Length of Stay in Neurologic Intensive Care Unit Patients, Diringer MN, Reaven NL, Funk SE, Uman GC. Critical Care Medicine 32: 1489-1495, 2004.
2. Treatment of fever in the neurologic intensive care unit with a catheter-based heat exchange system. Diringer MN. Critical Care Medicine 32: 559-564, 2004.
3. AHA guidelines. Published in Circulation. 2005;000:IV-84-IV-88.
4. Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest: The Hypothermia After Cardiac Arrest (HACA) Study Group. N Engl J Med 346:549-556, 2002.
5. Efficacy and Safety of Endovascular Cooling After Cardiac Arrest: Cohort Study and Bayesian Approach. Holzer M, Mullner M, Sterz F, Robak O, Kliegel A, Losert H, Sodeck G, Ray T, Zeiner A, Laggner AN. Stroke 37: 1792-1797, 2006.